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Acute Kidney Injury III: Clinical Manifestations01:29

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Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
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Updated: May 22, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

[Hypercalcemic crisis in intensive care].

M Haap1, O Tschritter, F Artunc

  • 1Medizinische Universitätsklinik Tübingen, Internistische Intensivstation, Eberhard-Karls-Universität Tübingen. michael.haap@med.uni-tuebingen.de

Deutsche Medizinische Wochenschrift (1946)
|May 17, 2012
PubMed
Summary
This summary is machine-generated.

A hypercalcemic crisis, a severe condition causing organ failure, demands immediate treatment. Prompt intervention, including hydration and medication, is crucial for survival and managing high calcium levels.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Oncology

Context:

  • Hypercalcemic crisis is a life-threatening condition characterized by severe hypercalcemia and multiorgan failure.
  • Untreated, it carries a high mortality rate, necessitating urgent diagnostic and therapeutic measures.
  • Rapidly rising calcium levels significantly impair nervous, renal, cardiovascular, and gastrointestinal systems.

Purpose:

  • To outline the causes, clinical presentation, and management strategies for hypercalcemic crisis.
  • To emphasize the critical need for prompt intervention in managing severe hypercalcemia.
  • To discuss both causal treatments and supportive therapies for hypercalcemic crisis.

Summary:

  • Hypercalcemic crisis, often caused by malignancy or primary hyperparathyroidism, presents with diverse organ system dysfunction.
  • Treatment involves addressing the underlying cause (e.g., malignancy treatment, surgery for hyperparathyroidism) and supportive care to lower calcium levels.
  • Key supportive therapies include rehydration with normal saline, bisphosphonates, loop diuretics, calcitonin, steroids, and calcimimetics. Continuous renal replacement therapy offers an alternative for acute calcium reduction.

Impact:

  • Highlights the critical nature of hypercalcemic crisis and the importance of timely intervention.
  • Provides a comprehensive overview of current and emerging therapeutic approaches.
  • Aids clinicians in the rapid diagnosis and management of this severe endocrine emergency.