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[Exogenous 3', 5'-cyclic diguanylic acid prevents caries formation in rats]
Wenjuan Yan1, Dehong Yang, Buling Wu
1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ywj918@sohu.com
Objective:
To investigate the effect of exogenous c-di-GMP in preventing dental caries formation in SD rats.
Methods:
Twenty-day-old SD rats with dental caries induced by S. Mutans infection were randomly divided into 3 groups for treatment with dental application of exogenous c-di-GMP, NaF solution or 0.9% NaCl, and changes in the bacterial number and scores of dental caries following the treatments were recorded.
Results:
Compared with 0.9% NaCl treatment, exogenous c-di-GMP treatment significantly lowered the scores of dental caries on the occlusal surface and smooth surface (P<0.05) but produced no obvious effect on the number of bacterial plagues (P>0.05).
Conclusion:
Exogenous c-di-GMP can be a novel agent for prevention and treatment of tooth decay.
