Related Experiment Video
Updated: May 22, 2026
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Efficacy of VBHOM to predict outcome following major lower limb amputation
Andrew J Patterson1, Andrew J Degnan, Stewart R Walsh
1MRIS Unit & University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK. andrew.patterson@addenbrookes.nhs.uk
Purpose:
This study tests an existing Vascular Biochemistry and Haematology Outcome Model (VBHOM) on independent data and presents further refinements to the model.
Methods:
Data from 306 patients who underwent lower limb amputation over a 4-year period were collated. Urea, creatinine, sodium, potassium, hemoglobin, white cell count, albumin, age, gender, mode-of-admission, and short-term mortality events were extracted from the database. This study tests an existing model and trains a new model for predicting mortality using forward stepwise logistic regression.
Results:
The existing model suggests a significant lack of fit (c-index = 0.665, P = .04). For the exception of gender and mode-of-admission, all predictor variables had significant univariate associations with short-term mortality (P < .05). The refined model included age, sodium, potassium, creatinine, and albumin and had good discriminatory power (c-index = 0.8, no evidence of lack of fit, P = .616).
Conclusions:
Our simplified model had good predictive ability and suggests redundancy in input variables used by the existing models.
