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Risk factors for temporomandibular joint arthritis in children with juvenile idiopathic arthritis
Matthew L Stoll1, Tyler Sharpe, Timothy Beukelman
1Department of Pediatrics, University of Alabama at Birmingham, 210 Children's Park Place North, Suite 210, 1601 4th Ave. South, Birmingham, AB 35233-1711, USA. mstoll@uab.edu
Insights
Temporomandibular joint (TMJ) arthritis affects 43% of children with juvenile idiopathic arthritis (JIA). Mouth-opening deviation is a key risk factor, suggesting routine MRI evaluation for JIA patients is needed.
Area of Science:
- Pediatric Rheumatology
- Medical Imaging
- Orthodontics
Background:
- Juvenile idiopathic arthritis (JIA) can affect various joints, including the temporomandibular joint (TMJ).
- TMJ involvement in JIA may lead to significant morbidity.
- Limited data exists on TMJ arthritis prevalence and risk factors in pediatric JIA patients.
Purpose of the Study:
- To determine the prevalence and MRI features of TMJ arthritis in children with JIA.
- To identify clinical and demographic risk factors associated with TMJ arthritis in this population.
Main Methods:
- Retrospective chart review of 187 JIA patients who underwent TMJ MRI.
- Demographic and clinical data abstraction.
- Univariate and multivariate analyses to identify risk factors for TMJ arthritis.
Main Results:
- TMJ arthritis detected in 43% of JIA patients via MRI.
- Mouth-opening deviation strongly associated with TMJ arthritis (OR 6.21).
- Smaller maximal incisal opening and shorter disease duration also increased TMJ arthritis risk.
Conclusions:
- TMJ arthritis is prevalent in children with JIA across all disease categories.
- Routine TMJ MRI evaluation is recommended for all JIA patients.
- Identifying risk factors like mouth-opening deviation can aid early detection and management.
Objective:
To determine the prevalence and features of temporomandibular joint (TMJ) arthritis by magnetic resonance imaging (MRI) among children with juvenile idiopathic arthritis (JIA), and to identify risk factors for TMJ arthritis.
Methods:
A retrospective chart review was performed on 187 patients with JIA who underwent a TMJ MRI at Children's Hospital of Alabama between September 2007 and June 2010. Demographic and clinical information was abstracted from the charts. Univariate and multivariate analyses were performed to identify risk factors for TMJ arthritis identified by MRI.
Results:
MRI evidence of TMJ arthritis was detected in 43% of patients, with no significant difference among JIA categories. The number of joints with active arthritis (exclusive of the TMJ) and the use of systemic immunomodulatory therapies were not associated with TMJ arthritis. Multivariable analysis revealed a strong association between mouth-opening deviation and TMJ arthritis (OR 6.21, 95% CI 2.87-13.4). A smaller maximal incisal opening and shorter disease duration were also associated with an increased risk of TMJ arthritis.
Conclusion:
TMJ arthritis was identified in a substantial proportion of children with JIA (43%) and affects all JIA categories. TMJ arthritis was present in some patients despite limited or otherwise quiescent disease and in the presence of concurrent systemic immunomodulatory therapy. Routine evaluation for TMJ arthritis by MRI is warranted for all children with JIA.
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