Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropathological changes and neurological function after spinal cord compression in the rat.

A Holtz1, B Nyström, B Gerdin

  • 1Department of Neurosurgery, University Hospital, Uppsala, Sweden.

Journal of Neurotrauma
|January 1, 1990
PubMed
Summary

This study details spinal cord injury in rats, observing cell changes and functional recovery after compression. Despite initial damage and delayed necrosis, significant recovery occurred within three weeks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Usefulness of discography, discoblock and a new mechanical method for identifying a painful segment/disc.

Neuro-Chirurgie·2022
Same author

Out-of-hospital cardiac arrest: Causes according to autopsy and electrocardiography - Analysis of 781 patients with neither hospital care nor prescribed medication during the preceding two years.

Resuscitation·2020
Same author

Posterolateral plate fixation with Pantalarlock® is more stable than nail fixation in tibiotalocalcaneal arthrodesis in a biomechanical cadaver study.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2019
Same author

[A rare differential diagnosis of acute appendicitis].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2015
Same author

[The Medical Officers Association of Finland during the 30 year period 1921-50].

Sotilaslaaketieteellinen aikakauslehti·2014
Same author

Long term health-related quality of life after burns is strongly dependent on pre-existing disease and psychosocial issues and less due to the burn itself.

Burns : journal of the International Society for Burn Injuries·2013

Area of Science:

  • Neuroscience
  • Pathology
  • Experimental Medicine

Background:

  • Compressive spinal cord trauma is a significant cause of neurological deficit.
  • Understanding the temporal dynamics of cellular changes is crucial for developing effective treatments.
  • Previous research has explored various pharmacological interventions with varying success.

Purpose of the Study:

  • To investigate the time course of cellular and morphological changes in the spinal cord following compressive trauma in a rat model.
  • To correlate these morphological changes with functional recovery over a 3-week period.
  • To identify potential targets for therapeutic intervention in spinal cord injury.

Main Methods:

  • A rat model of compressive spinal cord trauma was established.

Related Experiment Videos

  • Light microscopy was used to examine cellular changes at and distal to the injury site at various time points (1h, 4d, 9d, 21d).
  • Functional recovery was assessed using the inclined plane technique.

    • Main Results:

    • Initial compression caused swelling and hemorrhage, followed by necrosis and inflammatory cell infiltration by day 4.
    • Delayed necrosis was observed in the dorsal columns and pyramidal tracts, appearing by day 9 and persisting to day 21.
    • Myelin sheath splitting and enlarged periaxonal spaces were evident early (1h post-impact) and persisted, affecting white matter tracts distally.
    • Functional recovery was observed, with near pre-injury levels by day 21, despite ongoing morphological damage.

    Conclusions:

    • Compressive spinal cord injury induces both immediate and delayed pathological changes, including white matter damage.
    • Functional recovery can occur despite persistent morphological alterations, suggesting complex injury-recovery dynamics.
    • Further research employing diverse functional and morphological assessments is necessary to evaluate therapeutic interventions for spinal cord injury.