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Updated: May 22, 2026

Regulating Schwann Cell Growth by Nanosecond Pulsed Electric Field for Peripheral Nerve Regeneration In Vitro
Published on: May 3, 2024
The role of cells, neurotrophins, extracellular matrix and cell surface molecules in peripheral nerve regeneration
1Department of Anatomy, Faculty of Medicine, 50603 University Malaya, Malaysia.
Abstract:
Wallerian degeneration is a complicated process whereby axons and myelin sheaths undergo degeneration, and eventually are phagocytosed by macrophages and Schwann cells following nerve damage. Schwann cells proliferate and the endoneural tubes persist. In addition, neurotrophins, neural cell adhesion molecules, cytokines and other soluble factors are upregulated to facilitate regeneration. The important role of cellular components, neurotrophins, and extracellular matrix components, including cell surface molecules involved in this regenerative process, is highlighted and discussed in this review.
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