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Neurodevelopmental outcome of newborns with persistent pulmonary hypertension

Jaafar Rohana1, Nem Yun Boo, Viji Chandran

  • 1Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.

The Malaysian Journal of Medical Sciences : MJMS
|May 17, 2012
PubMed

Insights

Infants treated for persistent pulmonary hypertension of the newborn (PPHN) with inhaled nitric oxide (INO) or magnesium sulfate (MgSO4) faced developmental risks. Early intervention and follow-up are crucial for PPHN survivors.

Area of Science:

  • Neonatal care
  • Pediatric neurology
  • Developmental pediatrics

Background:

  • Infants with persistent pulmonary hypertension of the newborn (PPHN) treated with inhaled nitric oxide (INO) or magnesium sulfate (MgSO4) may experience developmental disabilities.
  • This study investigates the incidence of developmental disabilities in PPHN survivors at two years of age.

Purpose of the Study:

  • To determine the rate of developmental disabilities in infants who survived PPHN and received INO, MgSO4, or both during neonatal care.
  • To assess neurodevelopmental outcomes at 2 years of age in a cohort of PPHN survivors.

Main Methods:

  • Prospective follow-up of 16 PPHN survivors treated neonatally with intravenous MgSO4 and/or INO.
  • Neurodevelopmental assessment at 2 years using the Bayley Scales of Infant Development, 2nd Edition.
  • 11 (68.8%) infants completed the 2-year follow-up.

Main Results:

  • The median Mental Developmental Index (MDI) was 85 and the Physical Developmental Index (PDI) was 87.
  • Two infants (18.2%) exhibited developmental disability, defined as MDI scores below 70.

Conclusions:

  • PPHN survivors are at significant risk for developmental disabilities.
  • Integrating early intervention programs and long-term follow-up is essential for managing infants with PPHN.
Abstract

Keywords:
developmental disabilitiesmagnesium sulphateneurologynitric oxidepersistent pulmonary hypertension of newborn

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