Sodium (1R)-d-glucit-1-yl-sulfonate monohydrate

Area of Science:

• Crystallography
• Carbohydrate Chemistry
• Supramolecular Chemistry

Background:

• The reaction between d-glucose and sodium hydrogen sulfite yields crystalline addition products.
• Previous studies have investigated similar carbohydrate-sulfite adducts, such as the potassium salt.

Purpose of the Study:

• To elucidate the crystal structure of the d-glucose and sodium hydrogen sulfite monohydrate addition product.
• To analyze the intermolecular interactions, including cation coordination and hydrogen bonding, within the crystal lattice.
• To compare the complexation patterns with related carbohydrate-sulfite salts.

Main Methods:

• Single-crystal X-ray diffraction analysis was employed to determine the molecular and crystal structure.
• The crystallographic data were analyzed to identify independent molecules, coordination environments, and hydrogen bonding networks.

Main Results:

• The asymmetric unit contains three independent sodium cations, d-glucose-derived anions, and water molecules.
• The crystalline monohydrate forms an extended three-dimensional network structure.
• Independent molecules exhibit open-chain d-glucose structures with a sickle-like conformation, similar to the potassium salt, but with distinct complexation differences.

Conclusions:

• The study provides a detailed structural characterization of the sodium salt of the d-glucose-sulfite adduct.
• The observed three-dimensional network highlights the role of cation coordination and extensive hydrogen bonding in stabilizing the crystal structure.
• Differences in complexation patterns compared to the potassium salt offer insights into ion-specific interactions in carbohydrate adducts.