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Updated: May 22, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Bis(di-2-pyridyl-amine-κ(2)N(2),N(2'))platinum(II) dibromide monohydrate
1School of Applied Chemical Engineering, The Research Institute of Catalysis, Chonnam National University, Gwangju 500-757, Republic of Korea.
Abstract:
The asymmetric unit of the title compound, [Pt(C(10)H(9)N(3))(2)]Br(2)·H(2)O, contains two crystallographically independent half-mol-ecules of the cationic Pt(II) complex, two Br(-) anions and a lattice water mol-ecule; an inversion centre is located at the centroid of each complex. Each Pt(II) ion is four-coordinated in an essentially square-planar environment by four pyridine N atoms derived from the two chelating di-2-pyridyl-amine (dpa) ligands, and the PtN(4) unit is exactly planar. The chelate ring formed by the dpa ligand displays a boat conformation, with dihedral angles between the pyridine rings of 35.9 (2) and 41.0 (2)°. The complex cations, Br(-) anions and solvent water mol-ecules are linked by O-H⋯Br, N-H⋯Br, C-H⋯O and C-H⋯Br hydrogen bonds, forming a three-dimensional network.
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Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...