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Updated: May 22, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
(E)-2-(2-Hy-droxy-5-iodo-benzyl-idene)hydrazinecarboxamide
Abstract:
In the title mol-ecule, C(8)H(8)IN(3)O(2), there is an intra-molecular O-H⋯N hydrogen bond between the hy-droxy group and the imine N atom, which generates an S(6) ring. In the crystal, the carbonyl O atom accepts two different N-H⋯O hydrogen bonds, which connect mol-ecules with two R(2) (2)(8) motifs.
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The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...