Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Apolipoprotein E phenotypes and psoriasis].

T Imamura1, I Takata, K Tominaga

  • 1Department of Dermatology, Yamaguchi University School of Medicine.

Nihon Hifuka Gakkai Zasshi. the Japanese Journal of Dermatology
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hunter's glossitis and autoimmune gastritis: a case report.

QJM : monthly journal of the Association of Physicians·2023
Same author

Cigarette smoking and alcohol consumption associated with gastro-oesophageal reflux disease in Japanese men.

Scandinavian journal of gastroenterology·2003
Same author

Comparison of the effects of rebamipide with those of cimetidine on chronic gastritis associated with Helicobacter pylori in Mongolian gerbils.

Alimentary pharmacology & therapeutics·2003
Same author

Effects of latency period in a rabbit mandibular distraction osteogenesis.

International journal of oral and maxillofacial surgery·2003
Same author

Is eradication sufficient to heal gastric ulcers in patients infected with Helicobacter pylori? A randomized, controlled, prospective study.

Alimentary pharmacology & therapeutics·2002
Same author

Catheter dysfunction and thrombosis of double-lumen hemodialysis catheters placed in the femoral vein.

Clinical nephrology·2002

Apolipoprotein E (apoE) allele epsilon 2 may play a role in the development and severity of psoriasis vulgaris. This study found higher frequencies of apoE2 in patients compared to healthy individuals.

Area of Science:

  • Genetics
  • Dermatology
  • Biochemistry

Context:

  • Psoriasis vulgaris is a chronic inflammatory skin condition with complex etiology.
  • Apolipoprotein E (apoE) isoforms are known to influence lipid metabolism and immune responses.
  • Genetic variations in apoE may be associated with susceptibility and clinical presentation of various diseases.

Purpose:

  • To investigate the frequencies of apolipoprotein E (apoE) isoforms and alleles in patients with psoriasis vulgaris.
  • To compare apoE genotype distributions between psoriasis patients and healthy Japanese controls.
  • To explore potential correlations between apoE variants and clinical characteristics of psoriasis, such as onset age and disease severity.

Summary:

  • Gel isoelectric focusing identified apoE isoform and gene frequencies in 32 psoriasis vulgaris patients.

Related Experiment Videos

  • Patients exhibited higher frequencies of apoE E3/3 and allele epsilon 2, and lower frequencies of E3/3 and allele epsilon 3 compared to controls.
  • A trend towards higher frequencies of E3/2 and epsilon 2 was observed in early-onset, severe, and widespread forms of psoriasis, though not statistically significant.

    • Impact:

    • Suggests a potential role for apoE2 (allele epsilon 2) in the pathogenesis and clinical severity of psoriasis vulgaris.
    • Highlights the need for further research to confirm the association and elucidate the underlying mechanisms.
    • May inform future genetic studies and therapeutic strategies targeting apoE pathways in psoriasis.