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Updated: May 22, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
5,6,7,5'-Tetra-meth-oxy-3',4'-methyl-ene-dioxy-flavone monohydrate
Abstract:
THE TITLE COMPOUND [SYSTEMATIC NAME: 5,6,7-trimeth-oxy-2-(7-meth-oxy-1,3-dihydro-2-benzofuran-5-yl)-4H-chromen-4-one monohydrate], C(20)H(18)O(8)·H(2)O, was isolated from the popular Chinese medicinal plant Entada phaseoloides. In the crystal, inversion-related mol-ecules are joined by pairs of weak C-H⋯O hydrogen bonds. The dimers are further inter-connected by a bridging water mol-ecule via weak C-H⋯O(water) and pairs of (O-H)(water)⋯O hydrogen bonds into a linear tape running parallel to the b axis.
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