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Updated: May 22, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Redetermination of 1,3-diammonio-1,2,3-tride-oxy-cis-inositol dichloride
Christian Neis1, Günter J Merten, Philipp Altenhofer
1Fachrichtung Chemie, Universität des Saarlandes, Postfach 151150, D-66041 Saarbrücken, Germany.
Abstract:
The crystal structure of the title compound, C(6)H(16)N(2)O(3) (2+)·2Cl(-), has been reported previously by Palm [Acta Cryst. (1967 ▶), 22, 209-216] from Weisenberg camera data, with R1 = 10.5%, isotropic refinement of non-H atoms and H atoms not located. We remeasured a data set of the title compound and present a more precise structure determination. The asymmetric unit contains two unique 1,3-diammonio-1,2,3-tride-oxy-cis-inositol cations and four Cl(-) counter-ions. The cyclo-hexane rings of both inositol cations adopt chair conformations with two axial hy-droxy groups. An extended network of hydrogen bonds is formed. The four chloride counter ions are hydrogen bonded to the hydroxy and ammonium groups of the cations by N-H⋯Cl and O-H⋯Cl interactions. The cations are aligned into wavy layers by cation⋯cation interactions of the form N-H⋯O(ax), N-H⋯O(eq) and O(ax)-H⋯O(eq). Intramolecular hydrogen bonding between the axial hydroxy groups is, however, not observed.
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