Related Experiment Video
Updated: May 22, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
3-Amino-pyridin-1-ium 3-carb-oxy-benzo-ate
Abstract:
In the title organic salt, C(5)H(7)N(2) (+)·C(8)H(5)O(4) (-), the carb-oxy-lic group is nearly coplanar with the benzene ring [dihedral angle 1.9 (4)°] whereas the carboxyl-ate group is twisted relative to the benzene ring by 13.6 (4)°. In the crystal, N-H⋯O and O-H⋯O hydrogen bonds connect the components into a three-dimensional framework consisting of stacks of alternating pairs of anions and cations exhibiting π-π stacking inter-actions with centroid-centroid distances in the range 3.676 (2)-3.711 (1) Å. The π-π stacks extend along [110] and [-110].
Related Concept Videos
Carboxylic Acid Derivatives: Overview
Structures of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
IUPAC Nomenclature of Aldehydes
Nomenclature of Aryl and Heterocyclic Amines
Basicity of Heterocyclic Aromatic Amines

