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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: May 22, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue infection and miscarriage: a prospective case control study.

Peng Chiong Tan¹, May Zaw Soe, Khaing Si Lay

¹Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. pctan@um.edu.my

Plos Neglected Tropical Diseases

|May 17, 2012

Summary

Recent dengue infection is significantly associated with miscarriage. This mosquito-borne illness was detected more often in women experiencing miscarriage compared to those with viable pregnancies, even after accounting for other factors.

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Area of Science:

Infectious Diseases
Obstetrics & Gynecology
Epidemiology

Background:

Dengue is a widespread mosquito-borne viral infection globally.
Maternal dengue infection can lead to vertical transmission and pregnancy loss.
The specific link between dengue and miscarriage remains unclear.

Purpose of the Study:

To determine the association between recent dengue infection and miscarriage.
To investigate if dengue infection increases the risk of pregnancy loss.

Main Methods:

Case-control study comparing women with miscarriage (up to 22 weeks gestation) to controls with viable pregnancies.
Sera tested for dengue-specific IgM, non-structural protein 1 (NS1) antigen, and IgG using ELISA.
Statistical analysis adjusted for maternal age, gestational age, parity, and ethnicity.

Main Results:

Recent dengue infection (IgM or NS1 positive) was found in 5.2% of miscarriage cases versus 1.7% of controls.
This association remained significant after adjusting for confounding factors (AOR 4.2).
Recent dengue infection was detected more frequently in women experiencing miscarriage.

Conclusions:

A positive association exists between recent dengue infection and miscarriage.
Dengue infection may be a risk factor for early pregnancy loss.
Further research is warranted to understand the mechanisms.