Related Experiment Videos
Lymphoma presenting as a necrotic colonic mass.
Ioannis T Konstantinidis1, Michael R Probstfeld
1Ioannis T Konstantinidis, Department of Surgery, The University of Arizona College of Medicine, Tucson, AZ 85724-5058, United States.
World Journal of Gastrointestinal Surgery
|May 17, 2012
Summary
Primary colonic lymphomas are rare tumors. Early diagnosis of these colonic neoplasms is vital for effective treatment planning, especially when presenting as a necrotic mass.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Primary colonic lymphomas are uncommon neoplasms.
- Accurate pre-operative diagnosis is essential for treatment strategy.
- Colonic lymphomas can mimic other colonic masses.
Purpose of the Study:
- To present a case of colonic lymphoma manifesting as a necrotic colonic mass.
- To review current literature on the presentation, diagnosis, and treatment of isolated colonic lymphomas.
Main Methods:
- Case report.
- Literature review.
Main Results:
- The case highlights a colonic lymphoma presenting as a necrotic mass.
- Literature review synthesizes current evidence on clinical presentation, diagnostic modalities, and therapeutic options for primary colonic lymphomas.
Conclusions:
- Primary colonic lymphomas require careful pre-operative evaluation.
- Timely diagnosis and appropriate management are key for favorable outcomes in patients with colonic lymphoma.
Related Concept Videos
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
01:16Cellular Injury IV: Necrosis
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:27Diverticular Disease of the Colon
Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...