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Updated: May 22, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Angiogenetic pathway as a therapeutic target in renal cell carcinoma

Maristella Bianconi1, Mario Scartozzi, Luca Faloppi

  • 1Medical Oncology Clinic, AOU Ospedali Riuniti, Polytechnic University of the Marche Region, Ancona, Italy.

Analytical and Quantitative Cytology and Histology
|May 18, 2012
PubMed

Insights

Metastatic renal cell carcinoma (mRCC) treatment has been revolutionized by new targeted therapies. These therapies, primarily targeting the angiogenic pathway, have significantly improved outcomes for mRCC patients.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Metastatic renal cell carcinoma (mRCC) historically had poor prognosis due to therapy resistance.
  • Recent advancements have transformed mRCC treatment paradigms.

Purpose of the Study:

  • To review the impact of novel targeted therapies on mRCC treatment.
  • To highlight the efficacy of agents targeting the angiogenic pathway.

Main Methods:

  • Review of recent clinical trials and therapeutic strategies for mRCC.
  • Analysis of drugs targeting the vascular endothelial growth factor (VEGF) pathway.

Main Results:

  • New targeted therapies, particularly anti-angiogenic agents, have shown significant efficacy.
  • Monoclonal antibodies and tyrosine-kinase inhibitors are key therapeutic classes.

Conclusions:

  • The therapeutic landscape for mRCC has been revolutionized by targeted therapies.
  • VEGF-targeted agents represent a major advancement in mRCC management.

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Published on: April 12, 2017

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