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Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma
C Freudlsperger1, K Freier, J Hoffmann
1Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg, Germany. chr.freudlsperger@med.uni-heidel- berg.de
Summary
High Ki-67 expression in oral squamous cell carcinoma (OSCC) indicates better radiosensitivity and improved survival rates. This finding suggests Ki-67 can predict treatment response in OSCC patients receiving radiation therapy.
Area of Science:
- Oncology
- Radiation Oncology
- Cancer Biology
Background:
- The prognostic significance of Ki-67 expression in oral squamous cell carcinoma (OSCC) remains debated.
- Proliferating cells exhibit increased susceptibility to ionizing radiation.
Purpose of the Study:
- To investigate whether high Ki-67 expression, indicative of proliferation rate, predicts radiosensitivity in OSCC patients.
- To correlate Ki-67 expression with clinical outcomes in OSCC.
Main Methods:
- Immunohistochemistry was used to assess Ki-67 expression in 52 OSCC patients.
- Ki-67 levels were correlated with recurrence-free survival and overall survival in patients treated with surgery and radiation therapy.
Main Results:
- Low proliferative tumors (low Ki-67) had a significantly shorter mean recurrence time (27.5 months) compared to high proliferative tumors (49.5 months; p=0.048).
- The 5-year survival rate was 49% for low proliferative tumors versus 80% for high proliferative tumors (p=0.042).
Conclusions:
- Tumors with high proliferative activity (high Ki-67) demonstrate greater susceptibility to radiation therapy.
- Ki-67 may serve as a predictive marker for radiation therapy response in OSCC patients.