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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Updated: May 22, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

HIV: a growing concern in the elderly population.

Scott Martin Vouri1, Amie Taggart Blaszczyk

  • 1St. Louis College of Pharmacy, St. Louis, MO, USA. scott.vouri@stlcop.edu

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
|May 18, 2012
PubMed
Summary

Managing HIV in elderly patients presents unique challenges due to aging effects and comorbidities. Nonadherence and lack of lab results complicate treatment, requiring specialized care for this growing population.

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Area of Science:

  • Geriatric Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Improved HIV therapeutics increase the elderly HIV-infected population.
  • Aging affects pharmacokinetics and pharmacodynamics, complicating HIV treatment.
  • Elderly patients often have comorbidities that interact with HIV treatment.

Observation:

  • A 67-year-old male with HIV presented with nonadherence to medication and lab testing.
  • Complicating factors included poor renal function, drug interactions, and depression.
  • This case highlights challenges in managing HIV in older adults.

Findings:

  • Nonadherence and lack of laboratory results impede effective HIV treatment and monitoring.
  • Medication adjustments are necessary due to age-related metabolism and renal changes.
  • Comorbidities like depression and bone disease are linked to HIV and its treatment.

Implications:

  • Specialized education for pharmacists on geriatric HIV care is crucial.
  • Adherence and regular monitoring are vital for treatment efficacy in elderly HIV patients.
  • Comprehensive management strategies are needed for the growing geriatric HIV population.