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Updated: May 22, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Coronary artery bypass after Kawasaki disease]
Vera Santos1, Ana Sofia Simões, Ana Teixeira
1Serviço de Pediatria, Hospital de Faro, EPE, Faro, Portugal. verasantosm@yahoo.com
Insights
Kawasaki disease (KD) can lead to serious heart complications later in life, even after initial normal evaluations. Early diagnosis and consistent cardiac monitoring are crucial for managing this pediatric vasculitis.
Area of Science:
- Pediatric Cardiology
- Rheumatology
- Systemic Vasculitis
Background:
- Kawasaki disease (KD) is a leading cause of acquired heart disease in children, potentially causing coronary artery aneurysms and ischemic heart disease.
- Early diagnosis and treatment with immunoglobulin and aspirin are standard for KD.
- Long-term sequelae may manifest years after initial presentation.
Observation:
- A teenage boy diagnosed with KD at age seven had normal acute-phase echocardiograms.
- At age eleven, he presented with chest pain and exertional dyspnea.
- Exercise nuclear perfusion scans indicated hypoperfusion in the left anterior descending and right coronary artery territories.
Findings:
- Cardiac catheterization revealed proximal occlusions in both the left anterior descending and right coronary arteries.
- The patient underwent successful coronary artery bypass graft surgery, including internal mammary artery to LAD and saphenous vein graft to RC.
- Surgical intervention resulted in a favorable clinical outcome.
Implications:
- This case underscores the critical need for vigilant, long-term cardiological follow-up in children with a history of Kawasaki disease.
- Delayed complications of KD, such as coronary artery occlusion, can occur despite initial normal cardiac assessments.
- Prompt recognition and management of late-onset cardiac issues are vital for preventing severe ischemic heart disease in pediatric patients.
Abstract:
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology, which is the main cause of acquired heart disease in children in developed countries. The main complications result from the development of coronary aneurysms which can lead to ischemic heart disease. We present the case of a teenage boy with a diagnosis of KD at the age of seven. He was treated with gammaglobulin and aspirin and echocardiographic evaluation in the acute phase was apparently normal. At the age of eleven, he developed chest pain and exertional dyspnea. Nuclear perfusion scans with exercise revealed hypoperfusion of the left anterior descending (LAD) and right coronary (RC) artery territories. Cardiac catheterization showed occlusion of the proximal segments of both arteries. He underwent coronary artery bypass graft surgery (internal mammary artery bypass graft to the LAD artery and saphenous vein graft to the RC artery), with a good clinical result. This case report highlights the importance of early diagnosis and treatment of KD and regular cardiological follow-up, bearing in mind the potential late complications of this pediatric disease.
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