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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Triterpenoids.

Robert A Hill1, Joseph D Connolly

  • 1School of Chemistry, Glasgow University, Glasgow G12 8QQ, UK.

Natural Product Reports
|May 18, 2012
PubMed
Summary
This summary is machine-generated.

This review details the isolation and structure of various triterpenoids, including squalene derivatives and saponins. It synthesizes findings from 305 references on these natural compounds.

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Phytochemistry

Background:

  • Triterpenoids are a diverse class of organic compounds with significant biological activities.
  • Understanding their isolation and structure is crucial for drug discovery and chemical biology.
  • Previous reviews may not comprehensively cover the breadth of structural classes and recent advancements.

Purpose of the Study:

  • To provide a comprehensive overview of the isolation and structure determination of a wide range of triterpenoids.
  • To consolidate information on various triterpenoid skeletons, including squalene derivatives, protostanes, lanostanes, and others.
  • To serve as a reference for researchers in natural product chemistry and related fields.

Main Methods:

  • Literature review of scientific publications.
  • Systematic compilation of studies on triterpenoid isolation.
  • Analysis of structural elucidation techniques reported for diverse triterpenoid classes.

Main Results:

  • Detailed coverage of 305 cited references on triterpenoids.
  • Inclusion of numerous triterpenoid subclasses such as dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, and serratanes.
  • Emphasis on the structural diversity and isolation methodologies for these natural products.

Conclusions:

  • This review synthesizes a vast body of knowledge on triterpenoid chemistry.
  • It highlights the extensive structural diversity within the triterpenoid class.
  • The compilation serves as a valuable resource for ongoing research into triterpenoids and their applications.