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Related Experiment Video

Updated: May 22, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Intersection of reward and memory in monkey rhinal cortex.

Andrew M Clark1, Sebastien Bouret, Adrienne M Young

  • 1Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 18, 2012
PubMed
Summary
This summary is machine-generated.

The rhinal cortex (Rh) is crucial for predicting future reward values based on past experiences. Without a functioning Rh, animals fail to adjust their reward-seeking behavior according to learned reward histories.

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Last Updated: May 22, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
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Published on: August 30, 2017

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Behavioral Economics

Background:

  • Reward pursuit is driven by predicted value, which is context-dependent.
  • Reward prediction and valuation circuits involve dopamine neurons, prefrontal cortex, and basal ganglia.
  • The medial temporal lobe's role in reward valuation was previously unclear.

Purpose of the Study:

  • To investigate the role of the rhinal cortex (Rh) in using past reward memories to predict future reward values.
  • To determine if the Rh is essential for reward-based decision-making.

Main Methods:

  • Bilateral Rh lesions were performed on monkeys.
  • Monkeys performed a task where reward size varied across blocks of uncued trials.
  • Behavioral responses to varying reward magnitudes were analyzed.

Main Results:

  • Monkeys with Rh ablations were insensitive to changes in predicted reward value.
  • Lesioned monkeys responded as if expecting all rewards to be of equal magnitude.
  • Intact control monkeys appropriately adjusted behavior based on past reward values.

Conclusions:

  • The rhinal cortex (Rh) is critical for utilizing memories of previous rewards to predict the value of forthcoming rewards.
  • These findings highlight the Rh's importance in episodic memory and value-based decision-making.
  • The Rh plays a key role in establishing relationships between temporally interleaved events.