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Meningioma: a clinicopathological evaluation.
Nasrin Samadi1, Seyed Ali Ahmadi
1Department of Pathology, Sina Hospital, Hassan Abad Square, Tehran 11364, Iran.
The Malaysian Journal of Medical Sciences : MJMS
|May 18, 2012
Summary
This study analyzed meningioma epidemiology in Iran, finding good agreement between the WHO (2000) and Mahmood grading systems. Epidemiologic factors varied by tumor grade and location.
Area of Science:
- Neurosurgery
- Pathology
- Epidemiology
Background:
- No universally adopted grading system exists for meningiomas.
- Evaluating existing grading systems and their agreement is crucial for consistent diagnosis and treatment.
Purpose of the Study:
- To assess epidemiologic factors of meningioma in Iran.
- To determine the agreement between the World Health Organization (WHO) 2000 and Mahmood grading systems for meningiomas.
Main Methods:
- A 6-year retrospective review of 238 meningioma cases in Iran.
- Two independent pathologists utilized both WHO (2000) and Mahmood grading systems.
- Statistical analysis, including Kappa value, was used to compare grading systems.
Main Results:
- Meningiomas comprised 86.1% benign, 8% atypical, and 5.9% malignant cases.
- Female-to-male ratios shifted from a 1.9:1 preponderance in benign cranial tumors to 1:3.1 in malignant types.
- High agreement (Kappa=0.947) was observed between the Mahmood and WHO grading systems.
Conclusions:
- The WHO (2000) and Mahmood grading systems demonstrate substantial agreement for meningioma classification.
- Epidemiologic patterns, including sex ratio and age, differ across meningioma grades.
- Cerebral convexity was the most frequent intracranial tumor site, with meningothelial subtype being most common.
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