Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

What is the Immune System?

What is the Immune System?

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protonated phosphorus mononitride: Spectroscopic parameters and formation routes relevant for astrochemistry.

The Journal of chemical physics·2025

Same author

Immunomodulation profile of the biosimilar trastuzumab MYL-1401O in a bioequivalence phase I study.

Scientific reports·2024

Same author

Wildlife is imperiled in peri-urban landscapes: threats to arboreal mammals.

The Science of the total environment·2022

Same author

Subduction zone fluids and arc magmas conducted by lithospheric deformed regions beneath the central Andes.

Scientific reports·2021

Same author

Non-immediate drug hypersensitivity reactions secondary to intravitreal anti-vascular endothelial growth factors.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2021

Same author

TB and COVID-19 co-infection: rationale and aims of a global study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021

Search research articles

Related Experiment Video

Updated: May 22, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

[Common variable immune deficiency: what you need to know].

G Buss¹, D Comte, F Spertini

¹Service d'immunologie et allergie, Département de médecine CHUV, Lausanne. guillaume.buss@chuv.ch

Revue Medicale Suisse

|May 19, 2012

Summary

Common variable immune deficiency (CVID) is a primary immune deficiency affecting B cells and immunoglobulin production. Early diagnosis and immunoglobulin replacement therapy improve quality of life, but further research is needed.

More Related Videos

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Related Experiment Videos

Last Updated: May 22, 2026

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Area of Science:

Immunology
Genetics
Hematology

Context:

Common variable immune deficiency (CVID) is the most prevalent primary immunodeficiency.
It is characterized by impaired B lymphocyte differentiation and hypogammaglobulinemia.
Clinical features include recurrent infections, autoimmunity, and increased cancer risk.

Purpose:

To summarize current understanding of CVID.
To highlight recent advances in genetic mechanisms.
To emphasize the importance of early diagnosis and treatment.

Summary:

CVID involves B cell defects leading to low immunoglobulin levels.
Manifestations range from infections to autoimmune conditions and malignancies.
Genetic insights are emerging, and immunoglobulin replacement therapy is the standard treatment.

Impact:

Intravenous immunoglobulin therapy significantly improves patient survival and quality of life.
Further research into pathophysiology and early detection is crucial.
Delayed diagnosis negatively impacts morbidity and mortality rates.