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Updated: May 22, 2026
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics
Mamtimin Batur1, Upur Halmurat, Fu-Hua Hao
1College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China.
Objective:
To investigate plasma samples from neoplasm patients with phlegm-stasis or abnormal Savda syndrome, with NMR spectroscopy, and to analyze their metabolic varieties, characteristics and reciprocity.
Methods:
1H-NMR spectra were analyzed using the orthogonal projection to latent structure with discriminative analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of metabolites was determined by the Pearson's product - moment correlation coefficient.
Results:
Compared to the control group, neoplasm patients with phlegm - stasis or abnormal Savda syndrome had low concentrations of leucine, isoleucine, valine, alanine, tyrosine, histidine, citrulline, glycoprotein, glutamine, myo-inositol, scyllo-inositol, creatine, alpha-glucose, alpha-glucose and lactate (P < 0.05), and high concentrations of very low density lipoprotein, low density lipoprotein, unsaturated lipid, formate, acetone, acetate, acetoacetate, pyruvate, beta-hydroxybutyrate, carnitine and malonic acid (P < 0.05), with no significant differences between the phlegm - stasis and abnormal Savda syndrome patients.
Conclusions:
Neoplasm patients with different syndromes have very similar metabolic changes. A series of abnormalities such as immune dysfunction and oxidative - antioxidative imbalance, occur in neoplasm patients with abnormal Savda or phlegm - stasis syndrome.
