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Related Experiment Video

Updated: May 22, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Is assisted reproduction associated with abnormal placentation?

Jolly Joy¹, Caroline Gannon, Neil McClure

¹Obstetrics and Gynaecology, Mulhouse Building, Queen's University Belfast, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland. jolly.joy@belfastrust.hscni.net

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

|May 19, 2012

Summary

Artificial reproductive technologies (ART) and infertility impact placental health. ART pregnancies showed thicker placentas and more hematomas, potentially increasing perinatal risks.

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Area of Science:

Reproductive Medicine
Perinatology
Pathology

Background:

Artificial reproductive technologies (ART) and prolonged infertility are linked to pregnancy complications.
The role of placental dysfunction in these complications remains unclear.
Histological placental discrepancies may explain observed variances.

Purpose of the Study:

To compare placental histopathology in singleton pregnancies conceived via ART, spontaneous conception, and following untreated infertility (>1 year).

Main Methods:

Single pathologist examined placentae from 89 women (ART=33, infertility=17, control=39).
Exclusion criteria included smoking, medical history, and uterine anomalies.
Statistical analysis used ANOVA and chi-square tests.

Main Results:

ART placentas were significantly thicker than spontaneous conception placentas (P=0.02).
ART placentas had a higher incidence of hematomas (P=0.04).
No significant differences in placental shape, cord insertion, or microscopic lesions were found between groups.

Conclusions:

Placentas from ART pregnancies exhibit increased thickness and hematoma incidence.
These placental changes may contribute to increased perinatal risks.
Further research is needed to fully understand ART-related placental pathology.