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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Budd-Chiari disease in infancy: three cases.

P Mehta¹, I Shah, S Bhatnagar

¹Paediatric Liver Clinic, B. J. Wadia Hospital for Children, Mumbai, India.

Paediatrics and International Child Health

|May 19, 2012

Summary

Budd-Chiari syndrome (BCS) is rare in infants. This study highlights three infant cases of BCS, emphasizing its challenging diagnosis and poor prognosis in this age group.

Area of Science:

Pediatric Gastroenterology
Hepatology
Vascular Disorders

Background:

Budd-Chiari syndrome (BCS), characterized by hepatic venous outflow obstruction, is exceptionally rare in infants.
Early diagnosis and intervention are crucial for managing BCS, but presentation in infancy poses unique challenges.

Observation:

Three infant cases of BCS are presented, with ages ranging from 5 to 8 months.
Clinical presentations included abdominal distension, hepatomegaly, ascites, oliguria, and diarrhea.
Diagnostic imaging like Doppler ultrasound and CT scans were essential in identifying hepatic vein thrombosis or obstruction.

Findings:

Hepatic vein thrombosis was confirmed via CT scan in one case and ultrasound in another.
Obstructed hepatic veins were visualized in the third case using ultrasound.

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None of the infants presented with fever or jaundice initially.

Implications:

The rarity and non-specific symptoms of BCS in infants complicate early diagnosis.
The presented cases underscore the often-fatal outcome of infantile BCS despite diagnostic efforts.
Further research into early diagnostic markers and effective treatments for pediatric BCS is warranted.