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Updated: May 22, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis, spectral studies and antimicrobial activities of some 2-naphthyl pyrazoline derivatives
S P Sakthinathan1, G Vanangamudi, G Thirunarayanan
1PG & Research Department of Chemistry, Government Arts College, C-Mutlur 608102, Chidambaram, India.
Abstract:
A series of 2-naphthyl pyrazolines were synthesized by the cyclization of 2-naphthyl chalcones and phenylhydrazine hydrochloride in the presence of sodium acetate. The yields of pyrazoline derivatives are more than 80%. The synthesized pyrazolines were characterized by their physical constants, IR, (1)H, (13)C and MS spectra. From the IR and NMR spectra the C=N (cm(-1)) stretches, the pyrazoline ring proton chemical shifts (ppm) of δ(Ha), H(b) and H(c) and also the carbon chemical shifts (ppm) of δC=N are correlated with Hammett substituent constants, F and R, and Swain-Lupton's parameters using single and multi-regression analyses. From the results of linear regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial activities of all synthesized pyrazolines have been studied.
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