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Causes of in-hospital cardiac arrest and influence on outcome
Christian Wallmuller1, Giora Meron, Istepan Kurkciyan
1Department of Emergency Medicine, General Hospital of Vienna, Medical University of Vienna, Austria.
Insights
In-hospital cardiac arrest outcomes vary significantly based on the cause. Cardiac arrest originating from cardiac issues has a better prognosis than non-cardiac causes, highlighting the importance of identifying the cause for improved patient survival.
Area of Science:
- Cardiology
- Emergency Medicine
- Critical Care
Background:
- In-hospital cardiac arrest (IHCA) is a critical event with variable outcomes.
- Understanding the relationship between the cause of IHCA and patient prognosis is crucial for improving survival rates.
Purpose of the Study:
- To evaluate the relationship between the cause and outcome of in-hospital cardiac arrest.
- To analyze the impact of different cardiac arrest etiologies on patient survival and neurological condition.
Main Methods:
- Retrospective analysis of a cardiac arrest registry from a tertiary care hospital.
- Inclusion of resuscitation data, causes of arrest, and outcomes up to 6 months post-event.
- Analysis covered a 17.5-year period, involving 1041 patients.
Main Results:
- Cardiac causes accounted for 63% of IHCA, with acute myocardial infarction being the most frequent (35%).
- Pulmonary causes represented 15% of non-cardiac origins.
- Overall survival to good neurological discharge was 36%; cardiac causes had better outcomes (44%) than non-cardiac (23%).
- IHCA in the emergency department showed better outcomes compared to other hospital areas.
Conclusions:
- In-hospital cardiac arrest is predominantly caused by cardiac and pulmonary factors.
- Patient outcome is significantly influenced by the underlying cause of cardiac arrest, demonstrating considerable variability.
- Location of arrest within the hospital impacts survival, with the emergency department showing a better prognosis.
Aim Of The Study:
To evaluate the relationship between cause and outcome of in-hospital cardiac arrest.
Methods:
Retrospective analysis of resuscitation data, causes of cardiac arrest and outcome with a follow-up to 6 months of a cardiac arrest registry in an emergency department of a tertiary care hospital, covering a 17.5-year period.
Results:
Of 1041 patients, 653 were male (63%), the median age was 64 years (IQR 53-73), 51% suffered cardiac arrest in the emergency department. The first recorded rhythm showed PEA in 432 (41%), ventricular fibrillation in 404 (39%) and asystole in 205 (20%) patients. Cardiac arrest of cardiac origin occurred in 63% of all patients, with 35% of them due to acute myocardial infarction. Non-cardiac causes were mostly due to pulmonary causes (15% of all patients). Aortic dissection/rupture, exsanguination, intoxication and adverse drug reactions, metabolic, cerebral, sepsis and accidental hypothermia each ranged between 1 and 4% of the cohort. Of all patients, 376 (36%) were discharged in good neurologic condition. Overall, patients with cardiac causes had a significantly better outcome than those with non-cardiac causes (44% vs. 23%, p<0.01). Patients with pulmonary causes survived in 24%. The other subgroups showed widely divergent survival results (3-65%). Patients who had suffered cardiac arrest in the emergency department had a better outcome then patients of the regular ward or radiology department.
Conclusion:
In hospital cardiac arrest is caused mainly by cardiac and pulmonary causes, outcome depends on the cause, with a big variability.
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