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Updated: May 22, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
Published on: May 5, 2022
Contribution of mitochondria to pain in diabetic neuropathy
Natalia Hernández-Beltrán1, Carlos B Moreno, Angela María Gutiérrez-Álvarez
1Grupo de Investigación en Neurociencias, Universidad del Rosario, Bogotá, Colombia.
Abstract:
Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy.
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