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Updated: May 22, 2026

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
Published on: May 8, 2021
Pausing on the path to robustness
Mark L Siegal1, Christine Rushlow
1Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA. mark.siegal@nyu.edu
Abstract:
Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.
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