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Updated: May 22, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Follicular and mantle cell lymphoma characteristics present simultaneously in the same lymph node
Petra Korać1, Tomislav Horvat, Mirjana Mariana Kardum Paro
1*Medical School ‡Department of Molecular Biology, Faculty of Science, University of Zagreb †Institute of Pathology and Cytology §Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Merkur ∥Department of Medicine, Dubrava University Hospital, Zagreb, Croatia.
Summary
This study presents a unique case of follicular lymphoma with features of mantle cell lymphoma, suggesting a potential link and varied development pathways for small B-cell lymphomas.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Follicular lymphoma (FL) originates from germinal center B cells and typically lacks mantle zones.
- Transformation to aggressive lymphomas is known, but FL's connection to mantle cell lymphoma (MCL) is primarily seen in composite lymphomas.
Observation:
- A lymph node case exhibited both FL and MCL-like features within the same node.
- Immunohistochemistry revealed distinct cell populations and markers (CD20, CD10, BCL2, BCL6, cyclin D1, CD5, SOX11, Ki67, CD21) in different areas.
- Both components shared BCL2 rearrangement, SOX11 expression, and an identical clonal band, but lacked t(11:14).
Findings:
- The case demonstrates heterogeneous development in small B-cell lymphomas.
- It suggests a possible differentiation regression, where one lymphoma type may evolve from another.
Implications:
- This finding expands our understanding of lymphoma heterogeneity and potential developmental pathways.
- It highlights the importance of comprehensive analysis in diagnosing lymphomas with overlapping features.
- Further research into these differentiation pathways could inform therapeutic strategies.
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