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Updated: May 22, 2026
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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
A robust, high-sensitivity stealth probe for peptidases
Oliver Thorn-Seshold1, Monica Vargas-Sanchez, Sean McKeon
1Laboratoire de Chimie, CNRS, École Normale Supérieure de Lyon, 46 Allée d'Italie, F-69364 Lyon, France.
Chemical Communications (Cambridge, England)
|May 19, 2012
Abstract:
A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off-ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.
