Are there differences in the course of delusional disorders in different periods of time?

The results of two follow-up studies on delusional disorders of midlife of probands who fell ill in different periods of time with different access to treatment (modern pharmacotherapy not developed - developed) are compared with each other. The frequencies of uniform versus polymorphous and episodic versus chronic course did not differ in the two studies. These data suggest that the form of course belongs to the natural history of the disorder. The authors stress the importance of developing differentiated prognostic instruments, mainly in order to ameliorate prognostic hypotheses as a basis for rational therapeutic interventions.