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[Clinical and biochemical characterization of isoniazid-induced auto-antibodies]
C de B Granja1, M B Santiago, V S Viana
1Faculdade de Medicina, Universidade de São Paulo.
Revista Paulista De Medicina
|March 1, 1990
Abstract:
Isoniazid (INH) is one among many drugs capable of inducing autoantibodies and, in some cases, a lupus-like syndrome (LE). A longitudinal study was performed in 24 tuberculosis patients treated with INH to detect antibodies (A-AH) to total histones and fractions. Antinuclear antibodies were observed in two patients after treatment. Higher frequency of IgM-AH was also observed. IgM-AH binding to all fractions were observed in those serum samples exhibiting stronger ELISA reactivity. Conversely, binding to only H1 occurred when lower IgM-AH activity was tested. Correlations with clinical expressions of LE were not observed in the present study.