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Attempt to show inhibition by oxygen in the modifying factor assay
J R Archer1, A Claxson, A Edwards
1Bone and Joint Research Unit, London Hospital Medical College, United Kingdom.
Scandinavian Journal of Rheumatology. Supplement
|January 1, 1990
Abstract:
An Australian laboratory has demonstrated that antibodies to certain strains of enteric bacteria react with cells from HLA-B27-positive patients with a 'modifying factor' (MF) from these bacteria. These observations have proved difficult to reproduce. We investigated the possibility that oxygen inhibits the test by blocking B27, but we were unable to obtain consistent positive results.