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Related Experiment Videos

[Iatrogenic fluorosis. 2 cases].

M Welsch1, J G Bloch, D Stephan

  • 1Centre Régional de Pharmacovigilance Alsace et Service d'Hypertension et Maladies vasculaires, Hôpital Civil, Strasbourg.

Therapie
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

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Excessive fluoride intake from mineral water or niflumic acid can cause osteofluorosis, especially in patients with renal insufficiency. Careful monitoring of fluoride intake is crucial when treating osteoporosis.

Area of Science:

  • Bone Metabolism and Toxicology
  • Pharmacovigilance
  • Nephrology

Context:

  • Osteofluorosis is a rare bone disease characterized by increased bone density and abnormal bone histology.
  • Fluoride accumulation in bone can occur from various sources, including mineral water and certain medications.
  • Renal insufficiency significantly impairs fluoride excretion, increasing the risk of toxicity.

Purpose:

  • To report two new cases of osteofluorosis.
  • To highlight the potential risks of excessive fluoride intake from seemingly innocuous sources.
  • To emphasize the importance of patient history and renal function assessment in fluoride therapy.

Summary:

  • Two patients with severe renal insufficiency developed osteofluorosis due to long-term excessive fluoride intake: one from mineral water and another from niflumic acid.

Related Experiment Videos

  • Diagnosis was confirmed by bone densification on X-ray, hyperosteoidosis on histology, and elevated bone fluorine content.
  • Both cases underscore the need for caution when prescribing fluoride, particularly in patients with impaired kidney function.

    • Impact:

    • These cases emphasize the critical need for vigilance regarding cumulative fluoride exposure from all sources.
    • Recommendations include assessing plasma creatinine levels to calculate creatinine clearance before and during fluoride therapy.
    • Healthcare providers should carefully review patients' intake of fluoridated products and medications to prevent iatrogenic osteofluorosis.