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Henoch Schönlein purpura in Arab children. Analysis of 52 cases
Y K Abdel-Al1, Z Hejazi, H A Majeed
1Pediatric Department, Mubarak Hospital, Kuwait.
Insights
This study analyzed Henoch-Schönlein purpura in 52 Arab children over six years. While generally similar to other reports, it noted unusual presentations and a low incidence rate.
Area of Science:
- Pediatrics
- Rheumatology
- Nephrology
Background:
- Henoch-Schönlein purpura (HSP) is the most common childhood vasculitis.
- Previous studies on HSP epidemiology and clinical presentation are limited in the Arab population.
Purpose of the Study:
- To investigate the incidence, clinical features, and outcomes of Henoch-Schönlein purpura in Arab children.
- To identify any unique clinical manifestations or associations in this cohort.
Main Methods:
- Retrospective study of 52 Arab children diagnosed with HSP.
- Data collected over a 6-year period (October 1981–September 1987).
- Analysis of incidence, age at onset, clinical manifestations, and long-term outcomes.
Main Results:
- Estimated annual incidence of 6.7 per 100,000 children under 12.
- Mean age at onset was 5.6 years; no mortality observed in a 3-year follow-up.
- Identified unusual features: post-herpes virus infection (2 patients), temporo-mandibular joint involvement (1 patient), bullous lesions (1 patient), and flexural rash distribution.
Conclusions:
- HSP in Arab children shares similarities with international cohorts but presents with distinct features.
- The observed incidence and specific clinical variations warrant further investigation in diverse populations.
- Early identification and management are crucial, particularly for potential renal complications.
Abstract:
Over a period of 6 years (October 1981 through September 1987) 52 Arab children with Henoch Schönlein purpura were studied retrospectively. The annual incidence was estimated to be 6.7/100,000 children under the age of 12 years. The mean age at onset was 5.6 years, and in a mean follow-up period of three years, there was no mortality; three children developed intussusception and one child developed chronic renal failure and progressed to end stage kidney disease. The clinical profile of the disease was essentially similar to other reports. However, unusual features observed in this study included the development of the disease following herpes virus infection in two patients, the involvement of the temporo-mandibular joint in one and bullous lesions in another. The additional distribution of the typical rash over the flexor surface of the lower limbs in our patients was not reported before.
