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Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement
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Status of memory loss.

Parameswaran Mahadeva Iyer1, Joan Moroney, Gerard Mullins

  • 1Neurology Department, Beaumont Hospital, Dublin, Dublin, Ireland. parames68@gmail.com

BMJ Case Reports
|May 19, 2012
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of focal status epilepticus in a patient with Alzheimer's disease, potentially linked to perivascular oligodendroglial hyperplasia in the temporal lobe. Further research is needed to confirm this association.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Alzheimer's disease is characterized by amyloid plaques and neurofibrillary tangles.
  • Seizures can occur in Alzheimer's disease, but the underlying mechanisms are not fully understood.
  • Perivascular oligodendroglial hyperplasia is a rare finding in neurological conditions.

Observation:

  • A 72-year-old woman with no prior cognitive issues presented with new-onset seizure.
  • EEG indicated focal non-convulsive status epilepticus, and MRI revealed a left temporal lesion.
  • Temporal pole biopsy showed neuronal necrosis, astrocyte hyperplasia, amyloid plaques, and neurofibrillary tangles.

Findings:

  • Postmortem examination confirmed extensive Alzheimer's pathology.
  • Perivascular oligodendroglial hyperplasia was localized to the left temporal cortex.
  • This focal hyperplasia, alongside Alzheimer's pathology, may have precipitated the seizure.

Implications:

  • This case suggests a potential role for focal perivascular oligodendroglial hyperplasia in seizure generation in Alzheimer's disease.
  • It highlights a novel clinical-pathological correlation for focal epilepsy in the context of Alzheimer's.
  • Further investigation is warranted to elucidate the contribution of this specific pathology to seizures in Alzheimer's disease.