Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Cofactors and Coenzymes

Cofactors and Coenzymes

Enzymes are proteins made of amino acids. The functional group of each constituent amino acid catalyzes a wide variety of chemical reactions via ionic interactions or acid-base reactions. However, amino acids cannot catalyze oxidation-reduction and group transfer reactions and need to be aided by non-protein components called cofactors. Cofactors are also referred to as the chemical teeth of an enzyme.
Cofactors can be metallic ions or organic molecules called coenzymes. These types of helper...

Nitric Oxide Signaling Pathway

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinico-pathologic conference: fetomaternal transfusion.

Fetal and pediatric pathology·2006

Same author

Clinico-pathologic conference: an 11-year-old girl with lupus erythematosus, venous thromboses, and purpura fulminans.

Fetal and pediatric pathology·2006

Same author

Clinico-pathologic conference: status epilepticus in a 5-year-old girl.

Fetal and pediatric pathology·2006

Same author

Clinicopathologic conference: Barth Syndrome.

Fetal and pediatric pathology·2006

Same author

The usual childhood diseases: forgotten but not gone.

Fetal and pediatric pathology·2005

Same author

Lethal infantile cortical hyperostosis.

Fetal and pediatric pathology·2005

Search research articles

Related Experiment Video

Updated: May 22, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Nelson Textbook of Pediatrics.

Herbert H Pomerance

Archives of Pediatrics & Adolescent Medicine

|May 19, 2012

Summary

This pediatric textbook has evolved significantly, now featuring multiple editors and 212 contributors to cover the vast, rapidly expanding field of child health. Its comprehensive nature reflects a tradition of excellence in pediatric medicine.

Area of Science:

Pediatrics
Medical Education

Background:

The Nelson Textbook of Pediatrics has a long-standing tradition in medical education.
The scope of pediatric knowledge has expanded dramatically over time.
Traditional single- or dual-author textbooks are no longer feasible for comprehensive pediatric coverage.

Purpose of the Study:

To acknowledge the evolution of the Nelson Textbook of Pediatrics.
To highlight the collaborative effort required to produce a comprehensive pediatric resource.
To recognize the contributions of physicians and nurses in global child healthcare.

Main Methods:

The abstract describes the evolution of the textbook's authorship and scope.
It notes the transition from single-author volumes to a multi-editor and multi-contributor format.

More Related Videos

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Related Experiment Videos

Last Updated: May 22, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

The abstract emphasizes the increasing volume of pediatric knowledge.

Main Results:

The current edition features three editors and 212 contributors.
This collaborative model is necessary to address the explosion of knowledge in pediatrics.
The textbook continues its tradition of providing expert pediatric knowledge.

Conclusions:

The Nelson Textbook of Pediatrics exemplifies a modern, collaborative approach to medical education.
The extensive contributor base ensures comprehensive coverage of contemporary pediatrics.
The textbook serves as a vital resource for healthcare professionals dedicated to child well-being.