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Related Concept Videos

Crown Ethers02:36

Crown Ethers

Crown ethers are cyclic polyethers that contain multiple oxygen atoms, usually arranged in a regular pattern. The first crown ether was synthesized by Charles Pederson while working at DuPont in 1967. For this work, Pedersen was co-awarded the 1987 Nobel Prize in Chemistry. Crown ethers are named using the formula x-crown-y, where x is the total number of atoms in the ring and y is the number of ether oxygen atoms. The term 'crown' refers to the crown-like shape that these ether molecules take.
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...

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Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
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A crown ether appended super gelator with multiple stimulus responsiveness.

Shengyi Dong1, Bo Zheng, Donghua Xu

  • 1Department of Chemistry, Zhejiang University, Hangzhou, PR China.

Advanced Materials (Deerfield Beach, Fla.)
|May 19, 2012
PubMed
Summary

Researchers developed a novel super gelator capable of gelling diverse organic solvents efficiently. This supramolecular gel exhibits reversible transitions and can be shaped into stable objects.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Development of advanced gelation agents is crucial for materials science.
  • Super gelators offer enhanced properties for solvent encapsulation and material fabrication.

Purpose of the Study:

  • To design and synthesize a novel crown ether appended super gelator.
  • To investigate its gelation capabilities, transition properties, and moldability.

Main Methods:

  • Synthesis of a crown ether appended molecule.
  • Evaluation of gelation properties in various organic solvents.
  • Assessment of gel-sol transition reversibility and object formation.

Main Results:

  • The super gelator effectively gels a wide range of organic solvents.
  • It exhibits excellent gelation with low critical gelation concentration and short gelation time.
  • The supramolecular gels demonstrate reversible gel-sol transitions and can be molded into shape-persistent objects.

Conclusions:

  • The designed crown ether appended super gelator shows high efficiency and versatility.
  • Its reversible transitions and moldability open possibilities for advanced material applications.