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Updated: May 22, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Methyl 2,2-dimeth-oxy-8-oxo-1-oxaspiro-[4.5]deca-6,9-diene-3-carboxyl-ate
1School of Chemistry and Chemical Engineering, Southeast University, Southeast University Road 2, Jiangning District, 211189 Nanjing, People's Republic of China.
Abstract:
In the title mol-ecule, C(13)H(16)O(6), the cyclo-hexa-1,4-diene ring adopts a flat boat conformation (r.m.s. deviation from planarity = 0.060 Å) and the five-membered tetra-hydro-furan ring adopts an envelope conformation with the carboxyl group-substituted C atom as the flap. The dihedral angle at the spiro junction is 89.1 (1)°. In the crystal, mol-ecules are linked through weak C-H⋯O and van der Waals inter-actions.
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