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Updated: May 22, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-[(1,3-Thia-zol-2-yl)sulfamo-yl]phenyl 2,2,2-trifluoro-acetate
Abstract:
In the title compound, C(11)H(7)F(3)N(2)O(4)S(2), the 1,3-thia-zol-2-amine residue is almost perpendicular to the central benzene ring [dihedral angle = 84.3 (2)°]. There is a small twist between the benzene ring and the ester group [C-O-C-C torsion angle = 9.8 (6)°]. Thus, the mol-ecule has an L-shape. Inversion-related dimers are connected in the crystal packing by pairs of N-H⋯N hydrogen bonds formed between the amine H and thia-zole N atom via eight-membered {⋯HNCN}(2) synthons.
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