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Updated: May 22, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-(4-Chloro-phen-yl)-3-(morpholin-4-yl)urea.
1Microscale Science Institute, Department of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, People's Republic of China.
Summary
This study details the molecular structure of C(11)H(14)ClN(3)O(2), revealing a chair conformation of its morpholine ring. The crystal structure shows molecules forming inversion dimers through hydrogen bonds.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- The morpholine ring is a common heterocyclic motif in organic chemistry.
- Understanding molecular conformation and intermolecular interactions is crucial for predicting chemical properties and reactivity.
Purpose of the Study:
- To elucidate the crystal structure and molecular conformation of the title compound, C(11)H(14)ClN(3)O(2).
- To investigate the intermolecular interactions present in the solid state.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding networks was performed.
Main Results:
- The title molecule, C(11)H(14)ClN(3)O(2), adopts a chair conformation for its morpholine ring.
- In the crystal lattice, molecules aggregate into inversion dimers.
- These dimers are formed through intermolecular N-H⋯O hydrogen bonds.
Conclusions:
- The study provides detailed structural information on C(11)H(14)ClN(3)O(2).
- The observed chair conformation and hydrogen-bonded dimer formation offer insights into the molecule's solid-state behavior and potential intermolecular interactions.
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