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Updated: May 22, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
(E)-3-Anilino-2-benzoyl-3-(methyl-sulfan-yl)acrylonitrile
Abstract:
In the title acrylonitrile derivative, C(17)H(14)N(2)OS, the central amino-acryl-aldehyde O=C-C=C-NH unit, wherein an intra-molecular N-H⋯O hydrogen bond generates an S(6) ring motif, is approximately planar, with an r.m.s. deviation of 0.0234 (2) Å for the five non-H atoms. This plane makes dihedral angles of 41.04 (9) and 84.86 (10)° with the two phenyl rings. The dihedral angle between the two phenyl rings is 54.82 (10)°. An intra-molecular C-H⋯N hydrogen bond is also present. In the crystal, weak C-H⋯π and π-π inter-actions, with a centroid-centroid distance of 3.8526 (14) Å, are observed.
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