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Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.0K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.0K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

604
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
604
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.4K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.4K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

615
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
615
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

217
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
217
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.1K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.1K

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Related Experiment Video

Updated: Dec 20, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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Arsenic-induced pancreatitis.

Sean Connelly1, Krysia Zancosky, Katie Farah

  • 1Division of Gastroenterology, West Penn Allegheny Health System, 1307 Federal Street, Suite 301, Pittsburgh, PA 15212, USA.

Case Reports in Gastrointestinal Medicine
|May 19, 2012
PubMed
Summary

All-trans retinoic acid (ATRA) and arsenic trioxide are effective treatments for acute promyelocytic leukemia (APML). However, arsenic trioxide can rarely cause acute pancreatitis, a serious side effect to consider.

Area of Science:

  • Hematology
  • Oncology
  • Toxicology

Background:

  • All-trans retinoic acid (ATRA) and arsenic trioxide have revolutionized acute promyelocytic leukemia (APML) treatment.
  • These therapies offer significant benefits, generally outweighing their known risks.
  • The safety profiles of ATRA and arsenic trioxide are well-documented.

Observation:

  • Acute pancreatitis is an uncommon but potential adverse effect of arsenic toxicity.
  • This case highlights a patient with APML who developed pancreatitis during treatment.
  • The clinical presentation and diagnostic workup are crucial for identifying arsenic-induced pancreatitis.

Findings:

  • The patient with APML experienced acute pancreatitis.
  • Arsenic trioxide was identified as the likely causative agent.

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Related Experiment Videos

Last Updated: Dec 20, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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  • Prompt recognition and management of pancreatitis are essential.

    • Implications:

    • Clinicians should maintain a high index of suspicion for pancreatitis in APML patients treated with arsenic trioxide.
    • Understanding rare toxicities is vital for optimizing cancer therapy.
    • This case contributes to the understanding of arsenic's safety profile in APML treatment.