Nodular regenerative hyperplasia and portal hypertension in a patient with coeliac disease
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Published on: December 15, 2011
Erwin Biecker1, Hans-Peter Fischer, Michael Schepke
1Department of Gastroenterology and Hepatology, HELIOS Klinikum Siegburg, Ringstraße 49, 53721 Siegburg, Germany.
Abstract:
Nodular regenerative hyperplasia (NRH) of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and unexplained portal hypertension. Biopsy of the liver revealed NRH as the underlying cause. The patient did not suffer from an autoimmune, rheumatologic or lymphoproliferative disease. A thrombophilic disorder that might cause NRH was ruled out. Celiac disease is often associated with mild elevation of liver enzymes and steatosis of the liver, but the association with NRH was described in only a few patients. We discuss the possible relationship of celiac disease and NRH.
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