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Updated: May 22, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Orbitotemporal neurofibromatosis: case report.

Mahalakshmi Balasubramanyam¹, Goutham Cugati, Bipasha Mukherjee

¹Sankara Nethralaya, 18 College Road, Chennai 600034, India.

Case Reports in Ophthalmological Medicine

|May 19, 2012

Summary

Neurofibromatosis type 1 (NF-1) can cause severe cranioorbital plexiform neurofibromas, leading to disfigurement and vital structure compression. This case highlights management strategies for this rare NF-1 manifestation.

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Area of Science:

Ophthalmology
Oncology
Genetics

Background:

Neurofibromatosis type 1 (NF-1) affects approximately 60% of patients with plexiform neurofibromas.
These tumors can cause significant disfigurement and compress vital structures.
Malignant transformation of plexiform neurofibromas is a serious concern.

Observation:

A rare case of severe cranioorbital plexiform neurofibromatosis in a young male is presented.
The case involves significant involvement of the orbit and temporal region.
Associated focal and localized bone abnormalities, characteristic of NF-1, were noted.

Findings:

Plexiform neurofibromas in the cranioorbital region present unique diagnostic and management challenges.
Early identification and intervention are crucial for mitigating morbidity.

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Multidisciplinary approaches are often required for optimal outcomes.

Implications:

This case underscores the importance of recognizing cranioorbital manifestations in NF-1.
Understanding the classification and clinical features aids in tailored treatment planning.
Further research into novel therapeutic options for plexiform neurofibromas is warranted.