Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 22, 2026

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

New antifouling silica hydrogel.

Ángela A Beltrán-Osuna1, Bin Cao, Gang Cheng

  • 1Department of Polymer Engineering, University of Akron, Akron, Ohio 44325, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|May 22, 2012
PubMed
Summary

A novel antifouling silica hydrogel incorporating poly(carboxybetaine methacrylate) (pCBMA) was developed. This material significantly reduces protein adsorption, showing promise for biomedical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tetracene Diacid Aggregates for Directing Energy Flow toward Triplet Pairs.

Journal of the American Chemical Society·2024
Same author

System for Living ROMP of a Paramagnetic FeCl<sub>4</sub><sup>-</sup>-Based Ionic Liquid Monomer: Direct Synthesis of Magnetically Responsive Block Copolymers.

ACS macro letters·2022
Same author

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

Autophagy·2021
Same author

Characterization of an NDM-5-producing hypervirulent <i>Klebsiella pneumoniae</i> sequence type 65 clone from a lung transplant recipient.

Emerging microbes & infections·2021
Same author

Four new species of <i>Agaricus</i> subgenus <i>Spissicaules</i> from China.

Mycologia·2021
Same author

Appropriateness of antibiotic prescriptions in ambulatory care in China: a nationwide descriptive database study.

The Lancet. Infectious diseases·2021

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Biomaterial surface fouling by protein adsorption is a major challenge in biomedical applications.
  • Developing materials with inherent resistance to biofouling is crucial for improving device performance and longevity.

Purpose of the Study:

  • To synthesize and characterize a new antifouling silica hydrogel.
  • To evaluate the impact of incorporating poly(carboxybetaine methacrylate) (pCBMA) on silica hydrogel structure and properties.
  • To assess the antifouling performance of the developed hydrogel against protein adsorption.

Main Methods:

  • Poly(carboxybetaine methacrylate) (pCBMA) synthesis via atom-transfer radical polymerization.
  • pCBMA incorporation into silica hydrogel using a two-step acid-base-catalyzed sol-gel process.

More Related Videos

Fabrication of Superhydrophobic Metal Surfaces for Anti-Icing Applications
11:20

Fabrication of Superhydrophobic Metal Surfaces for Anti-Icing Applications

Published on: August 15, 2018

TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method
07:37

TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method

Published on: April 26, 2017

Related Experiment Videos

Last Updated: May 22, 2026

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

Fabrication of Superhydrophobic Metal Surfaces for Anti-Icing Applications
11:20

Fabrication of Superhydrophobic Metal Surfaces for Anti-Icing Applications

Published on: August 15, 2018

TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method
07:37

TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method

Published on: April 26, 2017

  • Supercritical CO(2) drying to form pCBMA silica aerogels.
  • Characterization using SEM, NMR, BET surface area analysis, and ELISA for protein adsorption.

    • Main Results:

    • SEM revealed changes in silica network porosity with varying pCBMA content.
    • BET analysis showed a 91% increase in surface area at 25 wt% pCBMA.
    • NMR confirmed complete pCBMA integration below 20 wt% polymer content.
    • ELISA demonstrated an 83% reduction in fibrinogen adsorption at 25 wt% pCBMA compared to unmodified silica.

    Conclusions:

    • The developed pCBMA-silica hydrogel exhibits significant antifouling properties.
    • The material's structure and surface area are tunable by adjusting pCBMA content.
    • This novel hydrogel holds potential for various biomedical applications requiring resistance to protein adsorption.