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Related Experiment Video

Updated: May 22, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Atopic dermatitis: correlation between non-damaged skin barrier function and disease activity.

Flavia A S Addor1, Roberto Takaoka, Evandro A Rivitti

  • 1Department of Dermatology, University of Sao Paulo Medical School, São Paulo-SP, Brazil.

International Journal of Dermatology
|May 22, 2012
PubMed
Summary

Biophysical measurements of skin barrier function, including corneometry and transepidermal water loss (TEWL), correlate with atopic dermatitis (AD) severity. These non-lesional skin assessments can help evaluate AD clinical severity.

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Last Updated: May 22, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Area of Science:

  • Dermatology
  • Biophysics

Background:

  • Atopic dermatitis (AD) is a chronic skin condition common in children, marked by itching, eczema, and dry skin (xerosis).
  • Assessing AD severity is crucial for effective management and treatment.

Purpose of the Study:

  • To investigate the relationship between biophysical skin barrier measurements and clinical severity of atopic dermatitis.
  • To determine if skin barrier function tests can serve as objective markers for AD severity.

Main Methods:

  • Biophysical measurements, including corneometry and transepidermal water loss (TEWL), were performed on 120 AD patients.
  • Serum immunoglobulin E (IgE) levels were also assessed.
  • Clinical severity was evaluated using Rajka and Langeland criteria.

Main Results:

  • A significant correlation was observed between corneometry, TEWL, and the clinical severity of AD.
  • Inverse correlations were found between corneometry and AD severity, and positive correlations between TEWL and AD severity.
  • Significant differences in mean corneometry and TEWL values were noted across mild, moderate, and severe AD cases (P < 0.001).
  • Corneometry showed a significant negative correlation with IgE levels, while TEWL demonstrated a significant positive correlation (P < 0.001).

Conclusions:

  • Biophysical measurements of skin barrier function in non-lesional skin are valuable indicators of AD severity.
  • These objective measurements can aid in the clinical assessment and monitoring of atopic dermatitis.